In 1993, at the Simion Research Center, the dangerous Gabriel kills many doctors and nurses and Dr. Florence Weaver, who is in charge of the case, says that it is time to cut out the cancer. In the present days, in Seattle, Madison Mitchell is pregnant after three miscarriages. When her drunken husband Derek Mitchell argues with her and beats her head against the wall, Madison passes out and when she awakes, she sees Derek murdered in a gruesome way. Madison loses the baby, and her younger sister Sydney Lake comforts her. Soon Madison has dreadful nightmares with a monster and horrible deaths. When she realizes that the murders are happening in real life, Madison and Sydney look for Police Detectives Kekoa Shaw and Regina Moss to report her dreams. What is the mystery behind the nightmares?